Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Characterization of a multigene-encoded sodium/hydrogen antiporter (sha) from Pseudomonas aeruginosa: its involvement in pathogenesis.
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The PA1054-PA1059 cluster encodes a Na+/H+ antiporter; the abstract reports mutation of PA1054 only.
"We disrupted PA1054 (a shaA homologue gene) and determined its effect on Na+ tolerance during growth, Na+ efflux, and pathogenicity in mice."
Single site mutations in the hetero-oligomeric Mrp antiporter from alkaliphilic Bacillus pseudofirmus OF4 that affect Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation.
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MrpE is required for normal membrane levels of other Mrp subunits and for complex formation.
"The results extended indications that MrpE is required for normal membrane levels of other Mrp proteins and for complex formation."
Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.
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MrpE is reported dispensable for ion transport in B. subtilis.
"However, in B. subtilis, it was reported that MrpE is dispensable for ion transport activity"
Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations.
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One mechanistic model has Na+ entering from the cytoplasm via MrpE.
"while sodium is taken up from the cytoplasm by MrpE and released to the periplasm at the interface of MrpA, MrpC, and MrpD"
Structure of an Ancient Respiratory System.
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Archaeal MBH contains an Mrp-like Na+-translocating module.
"The Na+-translocating unit, absent in complex I, resembles that found in the Mrp H+/Na+ antiporter"
UniProt entry Q9I4R7 (Q9I4R7_PSEAE)
Composition of PAINT node PTN002160407 (PTHR34584) and its leaf IBAs