ift-81 (A8DYR7, IFT81 ortholog) notes

Accession

A8DYR7 is the only UniProt entry for ift-81 (F32A6.2, CE41565, unreviewed). PMID:35969738 used the same WormBase protein CE41565.

Deep research status

Falcon timed out and the perplexity fallback was unavailable, so there is no deep-research file. The review was made by hand from the cached publications.

Summary with provenance

• IFT-81 is expressed in sensory neurons and sits at the ciliary base PMID:17535250. Loss-of-function mutants have behavioral defects and are small PMID:17535250.
• IFT-81 acts with IFT-74 in IFT PMID:17535250.
• Tubulin-binding module: the IFT81 CH domain binds the globular part of tubulin PMID:23990561. In human cells this binding is needed to build cilia PMID:23990561.
• In C. elegans, phosphorylation of IFT-74 lowers the tubulin affinity of IFT-74/81 PMID:35969738.

Curation decisions

• 22 GOA rows: 18 ACCEPT, 2 KEEP_AS_NON_CORE, 1 MARK_AS_OVER_ANNOTATED (growth), and 1 REMOVE (protein binding IPI).
• The MTOC (ARBA) and microtubule-based movement (ARBA) rows are accepted as correct general parents of ciliary basal body and intraciliary transport. Ancestry was checked in QuickGO.