GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:20523893

Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.

TOR RNAi extends lifespan of raga-1(GF) but not raga-1(ok386), placing raga-1 upstream of TOR.

"While raga-1(GF) exhibited increased lifespan with TOR RNAi treatment compared to empty vector, raga-1(ok386) did not. This suggests that, as in other systems, raga-1 is acting through TOR to exert its effects on lifespan."

PMID:22560223

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

PMID:23705068

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans.

Intestinal raga-1(Q63L) bypasses the elo-5 L1 arrest.

"We found that elo-5(−) animals containing this transgene bypassed the L1 arrest"

PMID:31411562

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans.

raga-1(ok386) increases AMPK T172 phosphorylation.

"AMPK T172 phosphorylation is increased in raga-1(ok386) null mutants compared to wild type animals"

PMID:37721956

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans.

Somatic degradation of RAGA-1 reduces phospho-RSKS-1.

"As expected, somatic AID of RAGA-1 or LET-363 resulted in decreased levels of phosphorylated RSKS-1"

PMID:40385374

Hyperactivation of mTORC1 by an endogenous raga-1 gain-of-function mutation does not reduce lifespan in C. elegans.

Endogenous raga-1(Q63L) hyperactivates mTORC1; the transgene does not.

"indicating that only the endogenous mutation is sufficient to increase mTORC1 activity"

PMID:31594908

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging.

file:worm/raga-1/raga-1-uniprot.txt

UniProt entry Q22743 (raga-1)