Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase.
-
ACP7 was identified as a novel human purple acid phosphatase closely related to the ~55 kDa plant enzymes, and a structural model built on the red kidney bean enzyme shows the canonical catalytic centre is present.
"A structural model for the human enzyme was constructed based
on the red kidney bean purple acid phosphatase structure. This model shows that
the catalytic centre observed in other purple acid phosphatases is also present
in this new isoform."
-
The sequences identified represent a novel subfamily of plant-like purple acid phosphatases in animals and humans.
"These observations suggest that the sequences identified in
this study represent a novel subfamily of plant-like purple acid phosphatases in
animals and humans."
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Affinage mechanistic annotation for ACP7 (human)