Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila.

Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.

The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor.

Evidence that Argos is an antagonistic ligand of the EGF receptor.

brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling.

Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis.

Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina.

Tip cell-derived RTK signaling initiates cell movements in the Drosophila stomatogastric nervous system anlage.

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila.

abdominal A specifies one cell type in Drosophila by regulating one principal target gene.

Reciprocal interactions between neurons and glia are required for Drosophila peripheral nervous system development.

Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.

DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways.

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration.

Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila.

Allocation and specification of the genital disc precursor cells in Drosophila.

Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster.

Multiple EGFR ligands participate in guiding migrating border cells.

Control of compartment size by an EGF ligand from neighboring cells.

Rhomboid cleaves Star to regulate the levels of secreted Spitz.

The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye.

Structural basis for EGFR ligand sequestration by Argos.

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.

Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.

Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway.

Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.

Structural basis for negative cooperativity in growth factor binding to an EGF receptor.

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery.

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection.

EGFR signaling in the brain is necessary for olfactory learning in Drosophila larvae.

Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.

Conserved miR-8/miR-200 defines a glial niche that controls neuroepithelial expansion and neuroblast transition.

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor.

Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor.

Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.

UniProt record for Drosophila melanogaster Protein spitz

FlyBase gene description for spi (DROME)

GO-CAM epidermal growth factor receptor signaling pathway via spi-Egfr (D.mel)