Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells.
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The human TMEM155 locus encodes a translated 63-aa peptide (hNEMEP) about 94% identical to mouse NEMEP.
"TMEM155 likewise encodes a 63 aa peptide (“hNEMEP”, sharing 93.6% identity with mNEMEP)"
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Human NEMEP binds human GLUT1 and GLUT3.
"Then, we confirmed that the homologous human NEMEP protein also interacts with the human GLUT1 and GLUT3 proteins"
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Mouse NEMEP is required for mesendoderm differentiation of mESCs and for normal glucose uptake.
"demonstrated that loss of NEMEP both significantly impaired mesendoderm differentiation and decreased glucose uptake"