Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mutation of human mu opioid receptor extracellular "disulfide cysteine" residues alters ligand binding but does not prevent receptor targeting to the cell plasma membrane.
Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X.
Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking.
The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor.
Regulation of mu opioid receptor internalization by the scaffold protein RanBPM.
Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.
A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.
Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.
Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.
Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.
The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C.
Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment.
Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.
Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells.
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.
The receptor:G-protein complex dissociates
The high affinity receptor complex binds to G-protein
The receptor:G-protein complex releases GDP
Opioid dissociates from MOR
The receptor:G-protein complex binds GTP
Opioid receptors bind opioid peptides
Liganded Gi-activating GPCR acts as a GEF for Gi
Expression of STAT6-upregulated plasma membrane proteins
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.
Structure of the µ-opioid receptor-G(i) protein complex.
mu-Opioid receptor knockout mice do not self-administer alcohol.
mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis.
Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells.
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Structural insights into µ-opioid receptor activation.
Structure-based discovery of opioid analgesics with reduced side effects.
Ligand-dependent G protein dynamics underlying opioid efficacy.