Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Comparative characterization of human and rat liver glycogen synthase.

Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0.

UniProtKB entry P54840 (GYS2_HUMAN), Glycogen [starch] synthase, liver

GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

Autoglucosylation of GYG2 complexed with GYS2-a

GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a

Autoglucosylation of GYG2 complexed with GYS2-b

Glycogen synthesis

GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2

NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2

PPP1R3C binds to glycogen:GYG2:GYS2

EPM2A dimer dephosphorylates phosphoglycogen-GYG2

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex

Defective GYS2 does not transfer glucose to growing glycogen chains

Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)