BABAM1 notes

2026-10-05 review (PAINT, affinage)

• MERIT40/NBA1: PMID:19261748
• Both complexes: PMID:21282113
• Accepted the complex, DSB repair, G2 checkpoint, IR response, DNA repair regulation and location rows.
• Response to vitamin B6 (NAS) is marked as an over-annotation: PLP sensing is done by SHMT2 (PMID:31142841).
• Identical protein binding, chromatin remodeling and nuclear body are kept as non-core. G2/M checkpoint NAS was accepted in revision 1 (parent of the core GO:0007095).
• Removed 17 GO:0005515 rows. BABAM2 and ABRAXAS1 are captured by the complex rows.

2026-10-05 revision (reviewer round 1)

• Nucleus and nucleoplasm rows now quote UniProt's Nucleus line (the previous line quoted stated the cytoplasm). The NAS rows were re-quoted for their own terms.
• NEW GO:0030674 adaptor activity (IDA, PMID:30533199) is the core MF PMID:30533199.
• ICL repair (PMID:26338419): MERIT40 is at psoralen ICLs and needed for BRCA1/RAD51/RPA recruitment, and Merit40-null MEFs are MMC-sensitive but not IR-sensitive. GO:0036297 is not asserted because no BRCA1-A member (nor BRCA1) carries it in GOA; it is raised as a suggested question. The IR-resistance (GO:0010212) rows stay accepted, as they rest on the curated IMP from the NBA1 genetic screen (PMID:19261749), not on the mouse null; that abstract does not state the cell system.
• HSC expansion in MERIT40 deficiency (PMID:25636339, thrombopoietin signalling) was considered and not annotated: it is a physiological phenotype with no defined molecular mechanism in the abstract.