The primary XB130 study establishes a signaling adaptor that activates Src and links EGF to downstream signaling and gene expression. It reports interaction motifs, kinase activation, knockdown effects and transcriptional reporters. The evidence supports specific kinase/adaptor roles rather than generic binding.
The full human818-residue sequence aligns to the horse850-residue model at88.6% identity. This supports the conserved adaptor mechanism and broad downstream cytokine/signaling claims. The cached abstract establishes IL-8; the separate DOI-linked full-paper excerpt documents the IL-6 result. Neither the Edison narrative nor ARBA is used as independent validation.
The reproducible alignment, source paths and hashes are in the paired comparison. Current UniProt sequences have not been proven identical to the original ProtNLM input sequences. Sequence anomalies are therefore recorded as model/transfer limitations, not as proven wrong-input pipeline errors.
The source excerpt file preserves the IL-6 sentence and full-paper URL because the publication cache is abstract-only. Consider tissue/condition-specific assays before treating cytokine phenotypes as universal horse physiology.
Every seeded annotation receives a current assessment. UNDECIDED marks unresolved source-specific or biological evidence; these are initial reviews rather than a claim that every original experimental assay has been independently reproduced or verified. The human Edison report is retained as a research synthesis and source-finding aid; decisive YAML excerpts cite primary publications, source records or reproducible analysis. The validator advisory to cite the deep-research file is deliberately not satisfied by citing AI prose as biological proof.