Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.
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Original identification and characterization of PMK-1 as a p38 MAPK
"Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans."
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Demonstration of kinase activity and activation by osmotic stress
"Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans."
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PMK-1 phosphorylates ATF-2 like mammalian p38
"Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans."
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
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Landmark paper establishing PMK-1 role in innate immunity
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity."
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PMK-1 is required for defense against P. aeruginosa
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity."
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Functions downstream of SEK-1 and NSY-1
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity."
Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
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PMK-1 phosphorylates SKN-1 in response to oxidative stress
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
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This leads to SKN-1 nuclear accumulation and gcs-1 expression
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
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Key paper linking PMK-1 to oxidative stress via SKN-1
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade.
A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.
Distinct innate immune responses to infection and wounding in the C. elegans epidermis.
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PMK-1 required for antimicrobial peptide nlp-29 expression
"Distinct innate immune responses to infection and wounding in the C. elegans epidermis."
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Functions in epidermal immunity against fungal infection
"Distinct innate immune responses to infection and wounding in the C. elegans epidermis."
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
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PMK-1 required for innate immunity and lifespan regulation
"Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity."
A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection.
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PMK-1 localizes to both nucleus and cytosol
"A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection."
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Required for tissue-specific immune response
"A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection."
An essential role for XBP-1 in host protection against immune activation in C. elegans.
Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.
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PMK-1 phosphorylates ATF-7 to regulate innate immunity
"Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans."
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ATF-7 switches from repressor to activator upon phosphorylation by PMK-1
"Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans."
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Key paper defining PMK-1 mechanism in immune gene regulation
"Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans."
Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.
Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity.
Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.
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PMK-1 phosphorylates RNT-1 during oxidative stress
"Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway."
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan.
Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
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PMK-1 nuclear localization in response to metals
"Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species."
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Regulates metallothionein expression through ATF-7
"Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species."
Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.
The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans.
Deep research report on pmk-1