EloC (Elongin C) review notes

Accession: E2QCI6 (expected accession; just fetch-gene DROME EloC resolved to Q7JWD6, which also has GOA rows, so the folder was refetched with --alias EloC on E2QCI6). Planned FlyBase gene-group module (not yet committed to modules/ on main): dmel_vcb_ubiquitin_ligase.

Literature journal

• VCB-Cul2: PMID:11006129; PMID:11006129
• Elongin complex and wing veins: PMID:24204884
• Socs36E/Cul5 JAK/STAT PMID:23885117; Dora TDMD ligase reported as CRL3 with EloB/C PMID:40328417; CrPV-1A hijacking PMID:30308158.

Decisions

• Core: GO:0160072 scaffold (BC-box adaptor, as for SkpA) contributing to GO:0061630; GO:0030891 VCB complex. Second core function: Elongin complex / Pol II elongation.
• ARBA general complexes -> MODIFY (GO:0140535 -> GO:0030891; GO:1990234 -> GO:0031462); GO:0006511 -> MODIFY GO:0043161.
• Viral process: MARK_AS_OVER_ANNOTATED (host ligase hijacked), same for EloB, Cul2, Roc1a.

Deep research (falcon, added after the initial review)

The falcon deep-research run finished after the initial commit and is now in EloC-deep-research-falcon.md. Its synthesis is consistent with the annotation decisions above; no review actions were changed.

Revision after PR #4471 review

• GO:0016032 viral process is now KEEP_AS_NON_CORE rather than MARK_AS_OVER_ANNOTATED: GO uses this term for host products that take part in a viral life cycle (CrPV-1A co-opts the host Cul2-EloBC ligase), matching the precedent in genes/ECOLI/DnaJ. This replaces the earlier viral-process decision above.
• GO:0140535 is now MODIFY to all four supported complexes (VCB, Elongin, Cul2-RING, Cul3-RING), not VCB alone.