"MxbM functions as the RR partner of **MxbD** (HK) in the **MxbDM** TCS"

"MxbM is required for **activation of the Ca2+-dependent methanol dehydrogenase system (mxa operon)** and is uniquely required for **repression of the lanthanide-dependent methanol dehydrogenase system (xox1 operon)**"

"MxbDM increases mxa expression while decreasing xoxF expression"

"A cascade model has been proposed in which **MxcQE activates mxbDM**"

"an **OmpR/PhoB-type DNA-binding domain** (winged helix-turn-helix), with WalR-like family assignment"

"the **phosphorylation state of the regulators and direct DNA binding have not been demonstrated**"

"the most plausible localization is **cytosolic**, acting on chromosomal promoters"

"MxbM is strongly inferred to be a DNA-binding response regulator from genetics/domain architecture, but the direct molecular mechanism remains unresolved"