Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain.
A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion.
Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond.
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.
ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.
von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function.
Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Platelet and von Willebrand factor interactions at the vessel wall.
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations.
Binding of ADAMTS13 to von Willebrand factor.
ADAMTS13 substrate recognition of von Willebrand factor A2 domain.
Mutations C1157F and C1234W of von Willebrand factor cause intracellular retention with defective multimerization and secretion.
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides.
Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi.
Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor.
Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen.
A pH-regulated dimeric bouquet in the structure of von Willebrand factor.
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Allosteric activation of ADAMTS13 by von Willebrand factor.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.
Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.
Inducible secretion of large, biologically potent von Willebrand factor multimers.
The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins.
MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database.
Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells.
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding.
The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor.
The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor.
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.
Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin.
Biochemistry and genetics of von Willebrand factor.
GPIb-IX-V binds to vWF:Collagen complex
factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
Interaction of integrin alphaIIbbeta3 with von Willebrand factor
Interaction of integrin alphaVbeta3 with von Willbrand Factor
Translocation of PTK2 to Focal complexes
Autophosphorylation of PTK2 at Y397
Recruitment of GRB2 to p-PTK2
Phosphorylation of pPTK2 by SRC
Interaction of integrin alphaIIb beta3 with Fibrinogen
Interaction of SOS with GRB2 bound to FADK1
Phosphorylation of BCAR1 by SRC-PTK2 complex
Recruitment of BCAR1 to PTK2 complex
Autophosphorylation of SRC
Clustering of Integrin alphaIIb beta3 complexes
Dephosphorylation of inactive SRC by PTPB1
SYK binds to integrin alphaIIb beta3
Thrombin binding to GP1b:IX:V
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
GP1b-IX-V binds 14-3-3-zeta
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
GP1b signaling involves c-Src
Exocytosis of platelet alpha granule contents
F8 variant does not bind von Willebrand factor
F8 variant is not cleaved by thrombin
factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst)
ADAMTS13 cleaves VWF multimer
VWF multimer binds to collagen type I
GPIb:IX:V binds to VWF multimer:collagen
VWF variant does not bind to collagen type I
VWF variant does not bind GPIb:IX:V
ADAMTS13 variant does not cleave VWF multimer
ADAMTS13 cleaves VWF variant multimer
GP1BA variant binds to VWF multimer:collagen
ADAMTS13 cleaves VWF multimer bound to FVIII
Falcon deep research report for human VWF
von Willebrand factor, Jedi knight of the bloodstream.
UniProtKB entry P04275 (VWF_HUMAN)