sucC (PA1588, P53593) notes

Literature

No deep-research provider was available. PubMed E-utilities returned HTTP 500
on 2026-11-05. The review rests on the full text of PMID:10671455 (cached) and
the reviewed UniProt entry (HAMAP MF_00558).

SucC and SucD were purified separately; the mixture is active PMID:10671455.
Dual ADP/GDP specificity PMID:10671455; can also make UTP and CTP at higher NDP
concentrations.
NDK-like phosphate transfer from ATP to GDP without succinyl-CoA PMID:10671455.
The phosphorylated protein is the 30-kDa alpha subunit PMID:10671455.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN000212531	GO:0042709 succinate-CoA ligase complex	6	208 (130 taxa)	GO:0042709, IDA, PMID:10671455 (PseudoCAP)	SOUND	Full text read: activity only from the mixture of purified SucC and SucD. The heteromer was not isolated, but it is reconstituted functionally.	E. coli SucC P0A836, human SUCLG2 Q96I99, mouse MGI:1306775/MGI:1306824, rat RGD:1305008	Yes. The other seeds are characterised SCS beta subunits; the term suits the whole SCS-beta clade.
PTN000212531	GO:0004775 succinate-CoA ligase (ADP-forming) activity	5	164 (126 taxa)	GO:0004775, IDA, PMID:10671455 (PseudoCAP)	SOUND	Full text read: forward and reverse SCS reactions with ATP/ADP on reconstituted enzyme.	E. coli SucC P0A836, human SUCLA2 Q9P2R7, Arabidopsis Q84LB6, rat RGD:1309397	Yes. The node term is right for the clade, and the GTP-specific SUCLG2 branch is excluded by a NOT at PTN000929335 (checked in leaf.gaf).

No PSEUDOCAP defect on the seed rows and no GO_CENTRAL defect.

Other decisions

GO:0046777 protein autophosphorylation (PseudoCAP IDA): REMOVE. The labelled
protein is SucD, and the label is the catalytic phosphohistidine. A PSEUDOCAP
WRONG_TERM defect is recorded (PROBABLE). Not a seed.
GO:0004550 NDP kinase activity: MARK_AS_OVER_ANNOTATED. The activity is real
in vitro but of unknown relevance, and a dedicated Ndk exists.
GO:0009142 NTP biosynthesis: KEEP_AS_NON_CORE.
GO:0003824 and GO:0046872: TOO_GENERAL.