Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Crystal structure of an Xrcc4-DNA ligase IV complex.
Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.
In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex.
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps.
Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism.
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.
Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair.
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.
XLF regulates filament architecture of the XRCC4·ligase IV complex.
XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.
A high-throughput scintillation proximity-based assay for human DNA ligase IV.
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
Structural insights into the role of domain flexibility in human DNA ligase IV.
APLF promotes the assembly and activity of non-homologous end joining protein complexes.
Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining.
Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction.
Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair.
DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells.
DNA Ligase IV regulates XRCC4 nuclear localization.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.
XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Architecture of the human interactome defines protein communities and disease networks.
LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis.
Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Multimodal cell maps as a foundation for structural and functional genomics.
DNA ligase IV from HeLa cell nuclei.
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.
Removal of repair proteins and ligation of the processed ends of the DNA double-strand break
Non-homologous end joining (NHEJ)
Association of XRCC4:DNA ligase IV complex with viral DNA ends
2-LTR formation due to circularization of viral DNA
POLL or POLM extends aligned DNA DSB ends to fill gaps
Nonhomologous End-Joining (NHEJ)
XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ
XRCC4:LIG4 ligates DNA DSB ends during NHEJ
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
DNA repair is limiting for haematopoietic stem cells during ageing.
UniProt entry P49917 (DNLI4_HUMAN)
LIG4 review notes and literature search log