Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Combined Automated Annotation using Multiple IEA Methods.
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.
Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.
Intestinal epithelial cells secrete exosome-like vesicles.
Cingulin interacts with F-actin in vitro.
Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.
SWI/SNF chromatin remodeling and cancer.
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
REST repression of neuronal genes requires components of the hSWI.SNF complex.
The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.
Identification of a polymorphic, neuron-specific chromatin remodeling complex.
Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.
Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Towards a proteome-scale map of the human protein-protein interaction network.
Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.
Identification of an actin-binding site in p47phox an organizer protein of NADPH oxidase.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.
Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation.
Molecular composition of IMP1 ribonucleoprotein granules.
Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1.
Microtubule-binding proteins CLASP1 and CLASP2 interact with actin filaments.
The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure.
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.
PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization.
HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.
High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex.
Regulated interactions of the norepineprhine transporter by the actin and microtubule cytoskeletons.
The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines.
Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A.
New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A.
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.
Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.
Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcription.
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex.
Defining the membrane proteome of NK cells.
Opening of tandem calponin homology domains regulates their affinity for F-actin.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Identification of FBXO25-interacting proteins using an integrated proteomics approach.
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Protein profile of exosomes from trabecular meshwork cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Next-generation sequencing to generate interactome datasets.
Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.
A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility.
Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions.
Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin.
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).
Protein disulfide isomerase directly interacts with β-actin Cys374 and regulates cytoskeleton reorganization.
Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.
Molecular mechanisms of disease-related human β-actin mutations p.R183W and p.E364K.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
G551D-CFTR needs more bound actin than wild-type CFTR to maintain its presence in plasma membranes.
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Widespread macromolecular interaction perturbations in human genetic disorders.
An inter-species protein-protein interaction network across vast evolutionary distance.
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer Cells.
Roles of tau protein in health and disease.
Architecture of the human interactome defines protein communities and disease networks.
A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.
HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Blood-Brain Barrier: From Physiology to Disease and Back.
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.
Network-based prediction of protein interactions.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release.
A variant form of beta-actin in a mutant of KB cells resistant to cytochalasin B.
Diversity and specialization of mammalian SWI/SNF complexes.
Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.
Extension of pseudopodia by myosin-X in a PI3K dependent manner
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin
Branching and elongation of mother and daughter filaments
Role of myosins in phagosome formation
Association of profilin with monomeric actin
L1 linked to actin cytoskeleton by ankyrin
N-WASP binds ARP2/3 and G-actin
Clathrin internalises EPH:EFN complexes
MigFilin associates with Filamin and F-actin
Linkage of L1 with treadmilling F-actin
Dephosphorylation of pL1 (Y1176)
p-MAPK2/3 phosphorylates HSP27
B-WICH complex binds rDNA promoter
IQGAPs bind F-actin, which is inhibited by calmodulin
CDC42:GTP:FMNL2 binds Profilin:G-actin
Activated FMNL3 binds G-actin
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
Profilin:G-actin binds MKL1
UCHL5 binds INO80 complex
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole
MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter
DGC complex binds AGRN and HSPG2
SS18-containing ATPase complex binds SMARCC dimer:SMARCDs:BICRAs:BRD9
PBRM1-containing ATPase complex binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD&:PHF10
SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3
Formation of neuronal progenitor BAF (npBAF)
SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10
CDH1-associated CTNNA1 binds VCL
CDH1 forms homotypic trans-dimers
CDH1-associated CTNNA1 binds F-actin
NuA4 complex actetylates H2A and H4
Deep research on ACTB function
Deep research on ACTB function (Cyberian)
Actin and Actin-Binding Proteins.
Actin polymerization and ATP hydrolysis.
Actin structure and function.
Essential nucleotide- and protein-dependent functions of Actb/β-actin.
Nuclear actin and actin-related proteins in chromatin remodeling.
De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.
SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment.
Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton.
NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.
Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.
Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.
β-Actin specifically controls cell growth, migration, and the G-actin pool.
The physiological significance of beta -actin mRNA localization in determining cell polarity and directional motility.
β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture.
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers.
Structures of the free and capped ends of the actin filament.
Conformation of actin subunits at the barbed and pointed ends of F-actin with and without capping proteins.
Nuclear actin structure regulates chromatin accessibility.
Divergent Contribution of Cytoplasmic Actins to Nuclear Structure of Lung Cancer Cells.
Exploring heterogeneous expression of beta-actin (ACTB) in bladder cancer by producing a monoclonal antibody 6D6.
The Actin Cytoskeleton and Actin-Based Motility.
Differential N-terminal processing of beta and gamma actin.
Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control.
Structural changes in muscle during contraction; interference microscopy of living muscle fibres.
Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation.