Annotation inferences using phylogenetic trees

All four IBA rows for this protein descend from the single PAINT node PTN001225435 (Eumetazoa) of PANTHER PTHR24381, which asserts nucleus, DNA-binding transcription factor activity (Pol II-specific), Pol II cis-regulatory region sequence-specific DNA binding, and regulation of transcription by RNA polymerase II.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Maps the UniProt subcellular location line (Nucleus; here an ARBA rule prediction) to GO:0005634.

file:XENTR/A0A8J0SCI2/A0A8J0SCI2-deep-research-falcon.md

Deep research summary for LOC101732730 in Xenopus tropicalis

The report correctly identifies the target (LOC101732730 / A0A8J0SCI2) and states explicitly that direct experimental literature on this gene is absent, so all functional conclusions are inferred from the C2H2 zinc finger domain architecture, Krueppel-family membership, and general C2H2-ZF biology.
The report's developmental inferences (gastrulation, germ layer formation, pluripotency exit, BMP/Wnt/Nodal pathway context) rest on the RefSeq-derived name "gastrula zinc finger protein XlCGF17.1-like" and on analogy to Xenopus Klf-family factors. KLFs belong to a different PANTHER family, and the name is an automatic RefSeq similarity name, so these inferences are not evidence and are not used in this review.

file:XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt

UniProt entry A0A8J0SCI2

A 265-residue unreviewed (TrEMBL) entry with eight tandem C2H2-type zinc finger domains spanning residues 37-260 (PROSITE PS50157 x8, PS00028 x8; SMART SM00355 x8) and a disordered polar N-terminal region (residues 1-27); no KRAB, SCAN or BTB effector domain is annotated. Its FUNCTION, SUBCELLULAR LOCATION and SIMILARITY comments and keywords are ARBA rule predictions, and its protein name is an automatic RefSeq similarity name.
The GN line gives the gene name LOC101732730 (RefSeq XP_012810399.1, Xenbase XB-GENE-29086363). PANTHER cross-references place the protein in family PTHR24381, subfamily SF440 ("OOCYTE ZINC FINGER PROTEIN XLCOF7.1-LIKE"); a live InterPro query on 2026-10-21 returned the same PTHR24381:SF440 match (E = 2.9e-63, residues 111-262), contradicting an earlier member-index entry that placed the accession in PTHR24377:SF929.

file:interpro/panther/PTHR24381/PTHR24381-review.yaml

PANTHER PTHR24381 family review (Krueppel C2H2-type zinc-finger family)

Assesses the four PTN001225435 IBD assertions inherited by this protein (nucleus, GO:0000981, GO:0000978, GO:0006357) as SOUND, notes that the node's seeds span both activators and repressors (hence the direction-neutral terms), and records the ZNF445-clade IRD as the family's only documented loss of cis-regulatory-region binding.