Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR.
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.
The layered structure of human mitochondrial DNA nucleoids.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Defining the human deubiquitinating enzyme interaction landscape.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
A proteome-scale map of the human interactome network.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
Mitochondrial translation requires folate-dependent tRNA methylation.
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
A reference map of the human binary protein interactome.
Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse.
Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization.
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
LONP1 binds mitochondrial inner membrane proteins
LONP1 degrades mitochondrial inner membrane proteins