Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Use of the ND evidence code for Gene Ontology (GO) terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

Combined Automated Annotation using Multiple IEA Methods

RGD ISO annotations to rat from other mammalian species

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.

Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.

The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.

The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking.

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin.

The role of phosphoinositide 3-kinase C2alpha in insulin signaling.

Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function.

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles.

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles.

Primary cilium-dependent autophagy drafts PIK3C2A to generate PtdIns3P in response to shear stress.

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

Role of the microRNA, miR-206, and its target PIK3C2α in endothelial progenitor cell function – potential link with coronary artery disease.

PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways.

PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation.

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.

UniProtKB D3ZTF6 record for rat Pik3c2a

Manual literature synthesis and sequence-motif check for rat Pik3c2a