Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Crystal structure of the FTO protein reveals basis for its substrate specificity.

N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5.

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein.

Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

Reversible methylation of m(6)A(m) in the 5' cap controls mRNA stability.

Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

Decoding m(6)Am by simultaneous transcription-start mapping and methylation quantification.

FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia.

Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB.

Structure-Based Design of a Highly Potent Dual-Competitive FTO Inhibitor for Targeted m(6)A Demethylase Inhibition in AML.

FTO depletion does not alter m(6)A stoichiometry in AML mRNA: a reassessment using direct RNA nanopore sequencing.

RNA demethylases demethylate N6-methyladenosine RNA