Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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Rv0898c was identified in the complete genome sequence of M. tuberculosis H37Rv
"The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content"
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry
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Rv0898c protein was detected by high-resolution mass spectrometry, confirming it is expressed at the protein level
"we identified 3176 proteins from Mycobacterium tuberculosis representing ~80% of its total predicted gene count"
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis
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Rv0898c is non-essential for in vitro growth of M. tuberculosis based on saturating transposon mutagenesis
"This work provides an authoritative catalog of essential regions of the M. tuberculosis genome"
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
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Starvation induces a persistence-like state in M. tuberculosis with upregulation of specific gene sets
"we have generated a model with which we can search for agents active against persistent M. tuberculosis and revealed a number of potential targets expressed under these conditions"
Mycobacterium tuberculosis Rv0899 defines a family of membrane proteins widespread in nitrogen-fixing bacteria
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The neighboring gene Rv0899 is part of the arf operon (Rv0899-Rv0901) required for ammonia secretion, but Rv0898c is on the opposite strand and is NOT part of this operon
"the rv0899 gene is part of an operon (rv0899-rv0901) that is required for fast ammonia secretion, pH neutralization, and growth of M"
Research notes for Rv0898c
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Rv0898c mRNA is upregulated after 96h of starvation per MycoBrowser annotation
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Rv0898c is detected in whole cell lysates but not in culture filtrate or membrane fractions
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No publications in PubMed specifically about Rv0898c function exist
OpenScientist hypothesis run: Rv0898c DUF2630 fold discovery
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Compute-driven AlphaFold + Foldseek analysis classified the DUF2630 fold as a two-helix antiparallel hairpin (weak uL29 ribosomal-protein similarity at 27% identity, twilight zone) but could not infer a molecular function, because the CATH 1.10.287 topology spans >600 unrelated superfamilies and the DUF2630 motif (CWDLLRQRR) has no characterized match. Supports retaining the ND annotation.
"The current ND (no data) molecular function annotation should be retained."