Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.
wt p53 dependent expression of a membrane-associated isoform of adenylate kinase.
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.
HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells.
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
'Srcasm: a novel Src activating and signaling molecule.
Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.
Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.
Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells.
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.
Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.
Bioinformatics and cellular signaling.
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.
Absence of Fyn and Src causes a reeler-like phenotype.
Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.
Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor.
The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.
Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.
Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.
Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.
GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.
Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination.
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
A Central Nervous System-Dependent Intron-Embedded Gene Encodes a Novel Murine Fyn Binding Protein.
Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.
Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.
Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells.
Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors.
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.
CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases.
Molecular cloning of Fyn-associated molecules in the mouse central nervous system.
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.
Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.
Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.
Interaction of Src kinases with c-Kit
Fyn phosphorylates Nmdar2b
Phosphorylation of FAK by Src kinases
Recruitment of FAK to NCAM1:Fyn in lipid rafts
Dock3 binds Fyn associated with Ntrk2
Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated
Csf1r trans-autophosphorylates on multiple tyrosine residues
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl
p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1
Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1
Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)
Dephosphorylation of NCAM1 bound pFyn
Autophosphorylation of NCAM1 bound Fyn
Recruitment and activation of Cdk5
UniProt record for Fyn (P39688)
Deep research report on Fyn (bioreason)
Deep research report on Fyn (bioreason-rl)
Deep research report on Fyn (falcon)