Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:19196974

The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response

FSHR-1 identified in screen of LRR-containing transmembrane receptors for immune function

"We screened all LRR-containing transmembrane receptors in C. elegans and identified the G protein-coupled receptor FSHR-1 as an important component of the C. elegans immune response"
Required for defense against Gram-negative and Gram-positive pathogens

"FSHR-1 as an important component of the C. elegans immune response to Gram-negative and Gram-positive bacterial pathogens"
Acts in the intestine

"FSHR-1 acts in the C. elegans intestine, the primary site of exposure to ingested pathogens"
Signals parallel to p38 MAPK pathway

"FSHR-1 signals in parallel to the known p38 MAPK pathway but converges to regulate the transcriptional induction of an overlapping but nonidentical set of antimicrobial effectors"
Regulates transcriptional induction of antimicrobial effectors

"FSHR-1 signals in parallel to the known p38 MAPK pathway but converges to regulate the transcriptional induction of an overlapping but nonidentical set of antimicrobial effectors"
May act as pathogen receptor or general immune booster

"FSHR-1 may act generally to boost the nematode immune response, or it may function as a pathogen receptor"

PMID:26360906

The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress

FSHR-1 delays pathogen accumulation in the intestine

"fshr-1(ok778) mutants have already accumulated a significantly greater amount of the fluorescent pathogen in their intestinal lumens (P<0.0001)"
Required for defense against diverse pathogens including PA14, S. aureus, E. faecalis

"fshr-1(ok778) mutants are more sensitive than wild-type worms to infection by diverse pathogens, including not only the Gram negative pathogen PA14, but also the Gram positive bacterial pathogens Staphylococcus aureus (P>0.01) and Enterococcus faecalis (P>0.05)"
Required for survival of oxidative stress (paraquat) and cadmium stress

"fshr-1(ok778) mutants died significantly more quickly in the presence of cadmium than wild-type worms (One-way ANOVA, F = 110.68; Tukey HSD test, P<0.05)"
NOT required for thermal stress survival

"The mean survival of fshr-1(ok778) mutants at 37°C is not significantly different from the survival of wild-type worms (One-way ANOVA, F = 0.42, P = 0.669), indicating that the fshr-1 pathway does not respond to the damage caused by high heat"
Regulates expression of immune and stress response genes

"when we examined the reported functions of the genes whose expression in infected worms depends on fshr-1, we observed that many were known antimicrobial infection response genes; in addition, 18% of fshr-1-regulated genes were associated with some type of cellular stress"
Required for induction of gcs-1 oxidative stress response gene

"fshr-1(ok778) mutant worms fail to induce expression of gcs-1::gfp upon PA14 infection"
Mediates learned pathogen avoidance behavior

"fshr-1(ok778) mutants are impaired in their ability to learn pathogen avoidance. 45% of fshr-1(ok778) mutants remain on a lawn of PA14 after 9 hours of exposure"
Acts in intestine for all characterized functions

"Expression of fshr-1 in the intestine is necessary and sufficient for its role in the response to infection by PA14"
Proposed to be indirect sensor of infection rather than direct pattern recognition receptor

"Rather than serving as a direct PRR like fellow LRR-containing TLRs and NLRs, we propose that FSHR-1 is an indirect sensor of infection"

file:worm/fshr-1/fshr-1-deep-research-falcon.md

Deep research report on fshr-1