GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:38534118

Hsp90, a team player in protein quality control and the stress response in bacteria

Bacterial HtpG/Hsp90 is a constitutive homodimer with an N-terminal ATPase domain, a middle domain, and a C-terminal dimerization domain; it undergoes an ATP-driven conformational cycle and collaborates with the Hsp70/DnaK system in client remodeling and refolding, lacking the dedicated cochaperone network of eukaryotic Hsp90.

"Bacterial HtpG is a constitutive homodimer dimerized via its C-terminal domain with three conserved domains per protomer (NTD, MD, CTD); it functionally collaborates with Hsp70 (DnaK) rather than a dedicated eukaryotic-type cochaperone network."

PMID:25303383

Genetic and phenotypic characterization of the heat shock response in Pseudomonas putida

In Pseudomonas putida, htpG mRNA is heat-inducible, rising within ~10 minutes of temperature upshift in a pattern correlating with RpoH (sigma-32) induction, supporting membership in the heat-shock regulon.

"htpG mRNA is heat inducible, with increased expression detectable within 10 minutes after temperature upshift; the induction pattern correlates with sigma-32/RpoH behavior."