Ptk7: exact selected product and human ortholog reference

Selected A0A8I6ALM9 has 1079 residues; reference Q13308 has 1070 residues.

Biopython PairwiseAligner global BLOSUM62, gap open -10, extension -0.5.

Reference interval Selected interval Identical residues
1–4 1–4 3
5–7 6–8 2
8–15 13–20 5
23–25 21–23 1
26–1070 35–1079 972

Reference feature mapping (sequence coverage does not establish retained function):

Reference feature Interval Mapped / length Identical
Signal: 1–30 23 / 30 12
Transmembrane: Helical 705–725 21 / 21 21
Domain: Ig-like C2-type 1 31–120 90 / 90 83
Domain: Ig-like C2-type 2 128–218 91 / 91 86
Domain: Ig-like C2-type 3 225–317 93 / 93 86
Domain: Ig-like C2-type 4 309–407 99 / 99 83
Domain: Ig-like C2-type 5 412–497 86 / 86 79
Domain: Ig-like C2-type 6 503–586 84 / 84 81
Domain: Ig-like C2-type 7 578–680 103 / 103 99
Domain: Protein kinase; inactive 796–1066 271 / 271 257

A shared segment does not establish that a truncated product folds, is expressed, localizes, or catalyzes the full-length reaction.

Inputs are the sibling frozen ProtNLM source and human ortholog reference JSON files. Reproduce with UV_NO_SYNC=1 uv run python compare_sequences.py from this directory.

Structural landmarks from PMID:32619402

Human position Human residue Selected position Selected residue
828 L 837 L
877 Y 886 Y
948 A 957 A
949 L 958 L
950 G 959 G

Residue conservation supports comparison with the human structure; it does not itself measure ATP binding or structure in rat.