ERS1 (At2g40940, Q38846) curation notes

2026-10-05 session (ethylene_signaling module)

• Deep research (just deep-research-falcon ARATH ERS1) failed (provider exit code 1); review based on cached publications and UniProt.
• Identity confirmed: ERS1_ARATH, Q38846, At2g40940, subfamily 1 ethylene receptor, lacks receiver domain.
• Ethylene binding: PMID:10938361; all five receptors bind ethylene PMID:15703053.
• Dimerization/membrane: PMID:10938361
• ER localization: PMID:19825542 -> nucleus ISM (AtSubP) removed.
• Genetics: dominant ers mutation gives insensitivity, ERS upstream of CTR1 PMID:7569898; null etr1-9 ers1-3 double strongly constitutive PMID:17224067
• Dual role controversy: PMID:20374664 -> reference flagged DISPUTED.
• Kinase: PMID:15358768 -> His kinase KEEP_AS_NON_CORE, phosphorelay terms over-annotated.
• CTR1 association: Y2H PMID:9560288; weak in pull-down PMID:25814663.
• Protein binding (TRP1, PMID:19567478) removed as uninformative (interaction itself is real).
• Core MF: ethylene receptor activity (GO:0038199), ethylene binding (GO:0051740), ER membrane.