Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Falcon deep research report for human HLA-DPA1
An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model.
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With the DPB1*05:01 beta chain held constant, an EBNA1-derived epitope was naturally processed and presented by the DPA1*02:02 pairing but not by the DPA1*01:03 pairing, so the DP alpha allele can determine which endogenously derived antigen is displayed.
"EBNA1564–583 was endogenously processed by HLA-DPA1*02:02/DPB1*0501 but not by HLA-DPA1*01:03/DPB1*0501"
HLA-DP(84Gly) constitutively presents endogenous peptides generated by the class I antigen processing pathway.
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HLA-DP heterodimers with Gly at beta-chain position 84 do not bind the invariant chain through the CLIP region and constitutively present proteasome-generated, TAP-transported endogenous peptides as well as endocytic ones.
"Importantly, these unique antigen presentation mechanisms enable DP84Gly to constitutively present intracellular peptides generated by the proteasome and transported to the ER by TAP, much like class I molecules."
A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44.
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The activating NK-cell receptor NKp44 binds directly to a subset of HLA-DP heterodimers, including HLA-DP401 (DPA1*01:03 with DPB1*04:01), but not to the HLA-DR or HLA-DQ molecules tested.
"the NKp44 Fc construct displayed significant binding to a subset of HLA-DP molecules, including the HLA-DP401 molecule"
HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.
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Interferon-gamma-stimulated cholangiocyte organoids carrying the DPA1*02:01~DPB1*01:01 haplotype upregulated HLA-DP, showed increased NKp44 binding, and triggered more NKp44+ NK-cell degranulation than HLA-DPB1 knockout organoids.
"Human cholangiocyte organoids expressing the PSC risk molecule HLA-DPA1*02:01-DPB1*01:01 upregulated HLA-DP on stimulation with IFN-γ and showed an increased binding of NKp44, while degranulation of primary NKp44+NK cells was reduced against HLA-DPB1 KO compared with HLA-DP expressing WT cholangiocyte organoids."
Crystal structure of HLA-DP2 and implications for chronic beryllium disease.
Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A multi-scale map of cell structure fusing protein images and interactions.
A zinc finger protein that represses transcription of the human MHC class II gene, DPA.
Expression of IFNG-stimulated genes
Phosphorylation of ITAM motifs in CD3 complexes
Phosphorylation of ZAP-70 by Lck
Dephosphorylation of Lck-pY505 by CD45
Phosphorylation of SLP-76
Inactivation of Lck by Csk
Phosphorylation of TBSMs in LAT
Phosphorylation of PLC-gamma1
Change of PKC theta conformation
Recruitment of ZAP-70 to phosphorylated ITAMs
Initial proteolyis of Ii by aspartic proteases to lip22
Generation of CLIP from lip10
Transport of MHC II:Ii complex to plasma membrane
Transport of MHC II:Ii complex along Golgi to TGN
Interaction of invariant chain trimer and MHC II alpha beta dimer
Uncoating of clathrin-coated vesicles and fusion with endosomes
Insertion of MHC II:Ii complex in to the plasma membrane
Cleavage of lip22 to lip10
TGN-lysosomal vesicle coat assembly
Recruitment of clathrin coated vesicle by Ii
Translocation of TGN-lysosome vesicle to lysosome
Internalization of MHC II:Ii clathrin coated vesicle
Formation of COPII vesicle
Trafficking of nonameric complex in the endocytic pathway
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
Formation of MHC II alpha beta heterodimer
Formation of nonameric complex
Fusion of COPII vesicle with Golgi complex
Loading of antigenic peptides
Disassociation of CLIP from MHC II
Transport of antigen loaded MHC II molecules to surface
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
Inactivation of LCK by PTPN22
PTPN22 dephosphorylates ZAP70
LAG3 (CD233) binds MHC II
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex
Dissociation of CANX from nonameric complex
Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
UniProt entry P20036 (HLA class II histocompatibility antigen, DP alpha 1 chain)