Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A map of the interactome network of the metazoan C. elegans.
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans.
-
LGG-2 is more closely related to human LC3 than LGG-1
"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans."
-
LGG-2 C-terminal glycine essential for lipidation and autophagosome localization
"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans."
-
LGG-2 and LGG-1 act synergistically in dauer formation and longevity
"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans."
-
LGG-2 localization modified during starvation and aging when autophagy induced
"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans."
The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.
-
LGG-1 acts upstream of LGG-2 during allophagy
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
-
LGG-2 controls autophagosome maturation through direct interaction with VPS-39
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
-
LGG-2 facilitates autophagosome-lysosome tethering via HOPS complex
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
-
Sequential pathway LGG-1 -> LGG-2 -> RAB-7 -> HOPS for autolysosome formation
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
-
G130A mutation abolishes autophagosome localization
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
-
HLH-30/TFEB drives expression of autophagy genes including lgg-2 during S. aureus infection
"Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes."
-
Autophagy genes essential for host tolerance of infection
"Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes."
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
-
LGG-2 required for xenophagic degradation of bacterial pore-forming toxin Cry5B
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
-
Autophagy-dependent membrane pore repair
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
-
lgg-2 RNAi reduces autophagic degradation of PFT
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
-
Crystal structure of LGG-2 with LIR peptide binding
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
-
LGG-2 recognizes LIR motifs in cargo receptors SQST-1, SEPA-1, EPG-2
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
-
LGG-2 interacts with ATG-7, ATG-3 for lipidation
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
-
LGG-2 interacts with ATG-16.1 and ATG-16.2 WD domains
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
-
LGG-2 less effective at promoting membrane fusion than LGG-1
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."