Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Identification of MUP1 as a regulator for glucose and lipid metabolism in mice.
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Source study for the mouse MUP1 metabolic, transcription and insulin receptor annotations transferred to rat P02761; MUP1 overexpression did not alter insulin receptor phosphorylation.
"Therefore, it is unlikely that MUP1 inhibits the hepatic gluconeogenic program by increasing insulin sensitivity in the liver."
Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice.
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Source study for the mouse MUP1 energy-expenditure, mitochondrial and thermogenesis annotations; the evidence is pharmacological elevation of circulating MUP1 in db/db mice.
"Chronic elevation of circulating MUP-1 in db/db mice, using an osmotic pump-based protein delivery system, increased energy expenditure and locomotor activity"
Male urinary protein-1 (Mup-1) expression in the female rat.
UniProt entry P02761 (Ratn1), Rattus norvegicus