Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter.
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Cloned human PAPST1 (SLC35B2), identified it as the Golgi PAPS transporter, and showed expression increases PAPS transport into the Golgi membrane fraction; the Drosophila ortholog slalom is essential for viability.
"significantly increased the transport of PAPS "
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
A reference map of the human binary protein interactome.
Biallelic variants in SLC35B2 cause a novel chondrodysplasia with hypomyelinating leukodystrophy.
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Biallelic SLC35B2 variants cause hypomyelinating leukodystrophy with chondrodysplasia (HLD26); patient fibroblasts show proteoglycan sulfation impairment and partial mislocalization of the protein away from the Golgi.
"we detected proteoglycan sulphation impairment in SLC35B2 patient "
The solute carrier superfamily interactome.
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Systematic AP-MS interactome of the human SLC superfamily; source of a physical interaction (protein binding) annotation for SLC35B2 (e.g. with GOLM1).
"Obtaining a robust protein interactome of SLC transporters"
SLC35B2,3 exchange cytosolic PAPS with Golgi PAP
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Reactome reaction describing SLC35B2 (and SLC35B3) importing cytosolic PAPS into the Golgi lumen while antiporting PAP back to the cytosol.
"Both proteins can transport PAPS from the cytosol to the Golgi lumen, simultaneously antiporting PAP back to cytosol"