Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Combined Automated Annotation using Multiple IEA Methods

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells.

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.

Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury.

Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON).

DJ-1 binds to mitochondrial complex I and maintains its activity.

Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly.

Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2).

Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex

Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I

ND4, ND5 bind the 550kDa complex to form the 815kDa complex

The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex

Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.

Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy.

From the 'black box' to 'domino effect' mechanism: what have we learned from the structures of respiratory complex I.