Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
c-di-AMP, a likely master regulator of bacterial K(+) homeostasis machinery, activates a K(+) exporter.
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KhtT binds the messenger directly and regulates a distinct membrane transport protein.
"We have confirmed c-di-AMP binding to KhtT and determined the crystal structure of this complex."
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The regulatory subunit restrains KhtU in the apo state.
"indicating that KhtT inhibits the function of KhtU, in accordance with our in vitro data and previous findings"
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Ligand activation depends on pH.
"demonstrating that c-di-AMP activates KhtTU and that pH increases its sensitivity to this nucleotide."