Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

file:human/ABRAXAS1/ABRAXAS1-goa.tsv

GOA annotation export for ABRAXAS1

GOA records the phylogenetic IBA source for the ABRAXAS1 GO:0008017 annotation.

"UniProtKB Q6UWZ7 ABRAXAS1 enables GO:0008017 microtubule binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN001272083|UniProtKB:Q15018 9606 Homo sapiens GO_Central BRCA1-A complex subunit Abraxas 1 20190430"

file:human/ABRAXAS1/ABRAXAS1-hypotheses/function-hypothesis-go-0008017/openscientist.md

OpenScientist hypothesis report for ABRAXAS1 GO:0008017

OpenScientist refutes microtubule binding as a direct ABRAXAS1 function.

"**Verdict: REFUTED / OVER-ANNOTATED (paralog carry-over).**"

PMID:17525340

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

ABRAXAS1/Abraxas binds BRCA1 BRCT repeats and RAP80, and is required for DNA damage resistance, G2/M checkpoint control, and DNA repair.

"Abraxas and RAP80 were required for DNA damage resistance, G(2)-M checkpoint control, and DNA repair."

PMID:17643121

CCDC98 targets BRCA1 to DNA damage sites.

PMID:18077395

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

PMID:19261746

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

PMID:19261748

MERIT40 facilitates BRCA1 localization and DNA damage repair.

CCDC98/ABRAXAS1 is a central component for assembly of the RAP80-containing BRCA1-A complex at DNA damage sites.

"CCDC98 as the central component that facilitates the assembly of this protein complex"

PMID:19261749

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.

PMID:19615732

Defining the human deubiquitinating enzyme interaction landscape.

PMID:20656689

Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.

ABRAXAS1 is required for BRCC36 DUB activity in the RAP80/BRCA1-A complex context, but is not itself the catalytic DUB.

"Abraxas and BRCC45 were essential for BRCC36 DUB activity within the RAP80 complex"

PMID:22369660

BRCA1 tumor suppressor network: focusing on its tail.

PMID:29656893

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

PMID:34591612

A protein interaction landscape of breast cancer.

PMID:35156780

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

PMID:36012204

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.

PMID:39009827

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.

ABRAXAS1 contains a functional nuclear localization signal around Arg361; the breast-cancer-associated R361Q mutation weakens importin/karyopherin binding approximately tenfold and increases cytoplasmic localization, providing a molecular basis for impaired nuclear import of the BRCA1-A complex.

Reactome:R-HSA-5683384

UIMC1 and FAM175A bind DNA DSBs

Reactome:R-HSA-5683385

Formation of BRCA1-A complex at DNA DSBs

Reactome:R-HSA-5683735

CHEK2 is recruited to DNA DSBs

Reactome:R-HSA-5683801

CHEK2 phosphorylates BRCA1

Reactome:R-HSA-5684052

PIAS4 SUMOylates MDC1

Reactome:R-HSA-5684071

RNF4 ubiquitinates MDC1

Reactome:R-HSA-5686685

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs

Reactome:R-HSA-5691411

BRCA1-A complex deubiquitinates K63polyUb-histone H2A

Reactome:R-HSA-5693551

Phosphorylation of BRCA1-A complex at multiple sites by ATM

Reactome:R-HSA-69891

Phosphorylation and activation of CHEK2 by ATM

file:human/ABRAXAS1/ABRAXAS1-uniprot.txt

ABRAXAS1 UniProtKB record

file:human/ABRAXAS1/ABRAXAS1-notes.md

ABRAXAS1 manual review notes and failed deep-research provenance

file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv

Proteostasis PN projected GO summary for ABRAXAS1

file:projects/PROTEOSTASIS/mappings/ubiquitin_proteasome_system.yaml

Proteostasis ubiquitin proteasome system mapping file

file:interpro/panther/PTHR31728/PTHR31728-entries.csv

PANTHER PTHR31728 reviewed protein members

PMID:26195665

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.