Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis.
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Human BAIAP2L2 co-localizes with clathrin plaques, supporting role in endocytosis
"human BAIAP2L2 (brain-specific angiogenesis inhibitor 1-associated protein 2-like 2) also tightly co-localizes with clathrin plaques"
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I-BAR proteins help generate membrane curvature for endocytosis
"The results from the present study suggest that I-BAR-containing proteins help generate the membrane curvature required for endocytosis and implies an unexpected role for IRSp53 family proteins in vesicle trafficking."
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
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Pinkbar is expressed in intestinal epithelial cells
"We show that a previously uncharacterized member of the I-BAR subfamily, Pinkbar, is specifically expressed in intestinal epithelial cells"
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Localizes to RAB13-positive vesicles and plasma membrane at intercellular junctions
"where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions"
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I-BAR domain has flat lipid-binding interface generating planar rather than tubular membrane structures
"Structural and mutagenesis analyses reveal that the BAR domain of Pinkbar has a relatively flat lipid-binding interface"
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Forms sheet-like oligomers in crystals and solution
"it assembles into sheet-like oligomers in crystals and in solution, which may explain its unique membrane-deforming activity"
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Promotes planar membrane sheet formation
"Notably, the BAR domain of Pinkbar does not induce membrane tubulation but promotes the formation of planar membrane sheets"
RHOF binds effectors at the plasma membrane
Ca<sup>2+</sup> entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips
Deep research review of BAIAP2L2 function
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BAIAP2L2 I-BAR domain mapped to aa 1-261
"Halford et al. mapped the I-BAR to approximately amino acids 1-261"
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Ca2+-dependent membrane association of I-BAR domain
"BAIAP2L2's I-BAR exhibited enhanced plasma membrane association when intracellular Ca2+ was elevated"
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Stereocilia tip localization requires MET channel activity
"Tip localization requires functional mechanotransduction (MET) channels and is lost upon acute pharmacological channel block or intracellular Ca2+ chelation"
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Forms tripartite complex with MYO15A and EPS8
"A tripartite complex of MYO15A (myosin XVa), EPS8, and BAIAP2L2 effectively targets to filopodia tips in cells"
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Loss of Baiap2l2 causes stereocilia destabilization and deafness
"loss of Baiap2l2 destabilizes transducing stereocilia and leads to deafness"
OpenScientist assessment of BAIAP2L2 epithelial Pinkbar function
OpenScientist focused report on BAIAP2L2/Pinkbar nucleoplasm localization