Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.
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CLEC-60 is upregulated 8.3-fold during S. aureus infection in C. elegans intestinal epithelial cells
"C-type lectin, von Willebrand factor, type A8.3AntimicrobialIntestine3"
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CLEC-60 is classified as an antimicrobial effector with predicted C-type lectin and von Willebrand factor type A domains
"C-type lectin, von Willebrand factor, type A+"
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Overexpression of the clec-60,61 gene cluster confers enhanced survival during S. aureus infection
"Transgenic animals carrying clec-60,61 cluster extrachromosomal arrays survived longer (LT50 = 54.2 h; N = 79; p = 0.019) during S. aureus infection than control animals bearing arrays composed of coinjection marker and clec-60::GFP promoter fusion (LT50 = 47.3 h; N = 95)."
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CLEC-60 is also induced by M. nematophilum infection
"M. nematophilum (UP)8.3C-type lectin"
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Expression is localized to intestinal epithelial cells
"C-type lectin, von Willebrand factor, type A8.3AntimicrobialIntestine3"
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The protein contains a signal peptide suggesting secretion
"C-type lectin, von Willebrand factor, type A+"