Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases.
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First cloning of human MMS19, showing interaction with XPB and XPD subunits of TFIIH
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Established nuclear localization and ubiquitous expression
The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor.
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MMS19 interacts with RAC3/NCOA3 and estrogen receptor
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Acts as AF-1-specific coactivator enhancing ER-mediated transcription
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Early interpretation as transcription adapter (superseded by Fe-S cluster delivery model)
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Defining the membrane proteome of NK cells.
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
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Discovery of MMXD complex containing MMS19, MIP18, XPD, CIAO1, and ANT2
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MMXD localizes to mitotic spindle during mitosis
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MMS19 knockdown causes improper chromosome segregation
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MMXD is distinct from TFIIH
Next-generation sequencing to generate interactome datasets.
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
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MMS19 forms complex with CIA proteins CIAO1, IOP1, and MIP18
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Cytoplasmic MMS19 binds multiple nuclear Fe-S proteins involved in DNA metabolism
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MMS19 functions as platform for Fe-S cluster transfer to DNA repair proteins
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MMS19 knockout mice die during preimplantation
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
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MMS19 identified as member of CIA machinery
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Functions as adapter between early-acting CIA components and Fe-S client proteins
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Client proteins include those for DNA replication, repair, and telomere maintenance
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Explains sensitivity of MMS19 mutants to DNA damage
IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.
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MMS19, MIP18, and CIAO1 form tight core complex
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IOP1 is external component
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MMS19 interacts directly with target proteins
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MIP18 bridges MMS19 and CIAO1
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
Architecture of the human interactome defines protein communities and disease networks.
Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase.
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MAGE-F1-NSE1 E3 ligase regulates CIA pathway through MMS19 ubiquitination
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MMS19 degradation affects Fe-S incorporation into DNA repair enzymes
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MAGE-F1 amplification in cancer increases mutational burden
Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Deep research report on MMS19