Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Domain mapping of the DNA binding, endonuclease, and ERCC1 binding properties of the human DNA repair protein XPF.
Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis.
Contribution of XPF functional domains to the 5' and 3' incisions produced at the site of a psoralen interstrand cross-link.
Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Defining the function of xeroderma pigmentosum group F protein in psoralen interstrand cross-link-mediated DNA repair and mutagenesis.
Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52.
Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.
gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells.
XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening.
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.
Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.
Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage.
Architecture of the human interactome defines protein communities and disease networks.
Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease.
Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease.
Mapping of interaction domains between human repair proteins ERCC1 and XPF.
Formation of ERCC1:XPF heterodimeric complex
ERCC1:XPF cleaves flaps generated by SSA
DNA polymerases delta, epsilon or kappa bind the GG-NER site
3'-incision of DNA by ERCC5 (XPG) in GG-NER
5'- incision of DNA by ERCC1:ERCC4 in GG-NER
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
DNA polymerases delta, epsilon or kappa bind the TC-NER site
3' incision by ERCC5 (XPG) in TC-NER
DNA nucleases bind monoubiquitinated ID2 complex
DNA nucleases unhook the interstrand crosslink (ICL)
ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA