Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage.
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.
FRMD4A-cytohesin signaling modulates the cellular release of tau.
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Intracellular trafficking of TREM2 is regulated by presenilin 1.
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway.
Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.
TREM2 function impedes tau seeding in neuritic plaques.
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease.
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Recruitment of SYK to p-DAP12
Interaction of DAP12 and TREM2
Phosphorylation of LAT by p-SYK
Phosphorylation of SLP-76 by p-SYK
PI3K phosphorylates PIP2 to PIP3
p85 regulatory unit of PI3K binds p-6Y-SYK
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
SEMA6D binds to PLXNA1:TREM2:DAP12