Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.
Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations.
The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
Notch1 control of oligodendrocyte differentiation in the spinal cord.
Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors.
A role for Wnt signalling in self-renewal of haematopoietic stem cells.
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock.
Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development.
Notch signaling controls multiple steps of pancreatic differentiation.
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
Functional diversity of notch family genes in fetal lung development.
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors.
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.
RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.
Essential role of endothelial Notch1 in angiogenesis.
Segmental expression of Notch and Hairy genes in nephrogenesis.
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.
DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
Notch1 is essential for postnatal hair follicle development and homeostasis.
Mutations in NOTCH1 cause aortic valve disease.
Direct regulation of intestinal fate by Notch.
Notch signaling coordinates the patterning of striatal compartments.
Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.
Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.
Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.
BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.
Notch 1 inhibits photoreceptor production in the developing mammalian retina.
Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.
Notch signaling is essential for ventricular chamber development.
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Monitoring Notch1 activity in development: evidence for a feedback regulatory loop.
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.
Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity.
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.
Notch1 represses osteogenic pathways in aortic valve cells.
Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression.
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.
Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation.
A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.
Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.
Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.
The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.
Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
Delta-like 1-Lysine613 regulates notch signaling.
Inhibitory role of Notch1 in calcific aortic valve disease.
Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Pten coordinates retinal neurogenesis by regulating Notch signalling.
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.
Notch4 reveals a novel mechanism regulating Notch signal transduction.
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
Notch-Tnf signalling is required for development and homeostasis of arterial valves.
Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling.
Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract.
BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions.
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.
Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced Failure of Neural Tube Closure.
Notch1 is required for the coordinate segmentation of somites.
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
Conservation of the Notch signalling pathway in mammalian neurogenesis.
RBP-L, a transcription factor related to RBP-Jkappa.
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.
Glycosylation of Pre-Notch by Fringe
Glucosylation of Pre-Notch by Poglut1
Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum
Gamma secretase cleaves Dner:Notch1 complex
Numb recruits Itch to Notch1
The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm
mNOTCH1 coactivator complex bind promoters of Hey genes
Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm
Rbpj:Nicd and Msgn1 bind the Lfng gene
Expression of Notch1 in presomitic mesoderm
Fucosylation of Pre-Notch by POFUT1
ADAM17 cleaves Notch1 at S2
FBXW7 binds phosphorylated NICD1
FBXW7 mediates ubiquitination of phosphorylated NICD1
Gamma secretase complex cleaves Cntn1-actived Notch1
Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD
mNICD1 Chimeric Enhancer Complex binds Hes1 promoter
Falcon deep research report on mouse Notch1 function
PANTHER PTHR45836 Notch and Slit guidance protein family metadata
Reviewed protein members for PANTHER PTHR45836