KGD2 (YDR148C, P19262) notes

• E2 (KE2, dihydrolipoyl transsuccinylase); pet G104 mutants lack KGDH activity PMID:2115121; disruption abolishes 2-OG-dependent NAD+ reduction PMID:2115121.
• 42% identity to E. coli SucB PMID:2115121. Reaction EC 2.3.1.61 with lipoyl cofactor [UniProt:P19262].
• Forms the core of KGDH [PMID:25165143 "confirming that Kgd2 forms the core of KGDH around which the other subunits assemble"; PMID:2072900].
• Nucleoid association: crosslinks to mtDNA, kgd2-null enhances abf2-null petites PMID:10869431; YMN-1 antigen = KE2 PMID:11926067.
• UniProt PATHWAY line lists "L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine" (mammalian DLST context); S. cerevisiae does not degrade lysine via saccharopine as a catabolic route, so this is not carried into the review.
• Glucose-repressed, HAP2/3-activated PMID:2115121.