Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors.
Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death.
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein.
The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells.
Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence.
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.
Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
Mxi2 promotes stimulus-independent ERK nuclear translocation.
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase.
Structural basis for the catalytic mechanism of phosphothreonine lyase.
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.
Phosphorylation of U24 from Human Herpes Virus type 6 (HHV-6) and its potential role in mimicking myelin basic protein (MBP) in multiple sclerosis.
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
The ERK signaling cascade--views from different subcellular compartments.
High-throughput RNAi screening reveals novel regulators of telomerase.
TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells.
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Toward an understanding of the protein interaction network of the human liver.
Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.
Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells.
Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.
MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase.
Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase.
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
The protein interaction landscape of the human CMGC kinase group.
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.
MFAP3L activation promotes colorectal cancer cell invasion and metastasis.
Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.
ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay.
miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.
Regulation of Microtubule Assembly by Tau and not by Pin1.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.
A gut-derived hormone regulates cholesterol metabolism.
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
Multimodal cell maps as a foundation for structural and functional genomics.
ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.
Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.
Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.
Falcon deep research report on MAPK1