Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP.
Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP.
Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP.
Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX.
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene.
Mitochondrial protein degradation
CLPXP binds mitochondrial matrix proteins
CLPXP degrades mitochondrial matrix proteins
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease.
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Comparative analysis of mitochondrial proteomes across the tree of life.
A salvage pathway maintains highly functional respiratory complex I.
Perrault syndrome type 3 caused by diverse molecular defects in CLPP.
Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease.
Exome analysis identified a novel missense mutation in the CLPP gene in a consanguineous Saudi family expanding the clinical spectrum of Perrault Syndrome type-3.
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.
Biochemical and functional characterization of human phospholipid scramblase 4 (hPLSCR4).
UniProt Q16740: protected CLPP record
Attributed original CLPP primary excerpts and public access locators