Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells.
Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases.
Nucleocytoplasmic shuttling of Bruton's tyrosine kinase.
Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein.
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases.
B cell signaling. Introduction.
Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.
Btk-dependent regulation of phosphoinositide synthesis.
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.
Regulated association of protein kinase B/Akt with breast tumor kinase.
Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase.
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains.
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response.
Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.
Widespread macromolecular interaction perturbations in human genetic disorders.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.
An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency.
BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells.
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.
BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.
Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK).
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 forms a complex with TIRAP:activated TLR2/4
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
Multiple IRAK1 autophosphorylation steps
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
TIRAP is phosphorylated by BTK
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Activation of RAC1 by VAV2/3
Recruitment of VAV and BTK to p-SLP-76
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Fc epsilon receptor (FCERI) signaling
Activated TLR2/4:TIRAP interacts with BTK
Phosphorylation of TEC kinases by p-SYK
Hydrolysis of PIP2 by PLCG
Autophosphorylation of BTK/ITK
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4
Defective MyD88 does not oligomerize within the activated TLR2/4 complex
Defective MyD88 does not bind MAL(TIRAP):TLR2/4
G beta-gamma complex and PIP3 recruit BTK to membrane
BTK in G alpha (12)-BTK complex is activated
BTK in PIP3:BTK:G beta-gamma complex is activated
BTK in active Gq-BTK complex is activated
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)
Gq-BTK complex dissociates to Active BTK and Gq
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia.
RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.
The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection.
Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA).
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model.
Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis.
Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages.
Development and pharmacological validation of novel methods of B cell activation in rat whole blood.
Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor.