Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis.
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Nicked beta2GPI binds plasminogen and suppresses plasmin generation.
"Nicked beta(2)-GPI also suppressed plasmin generation up to 70% in the presence of tissue plasminogen activator, plasminogen, and fibrin. Intact beta(2)-GPI lacks these properties."
Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells.
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beta2GPI is a phospholipid-binding plasma protein; p276-290 holds the major PL-binding site.
"p276-290), which contains the major PL-binding site"
beta(2)-glycoprotein I protects J774A.1 macrophages and human coronary artery smooth muscle cells against apoptosis.
The role of beta2-glycoprotein I (beta2GPI) in the activation of plasminogen.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Plasmin-cleaved beta-2-glycoprotein 1 is an inhibitor of angiogenesis.
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Plasmin-cleaved beta2GPI is anti-angiogenic.
"Here, we show that cleavage of the kringle domain at Lys317/Thr318 switches its function to a regulator of angiogenesis."
Self-interaction of soluble and surface-bound beta2-glycoprotein I and its enhancement by lupus anticoagulants.
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beta2GPI self-associates at surfaces.
"Here we show that beta2GPI, which is monomeric in solution, self-interacts at the interface of soluble and surface-bound molecules."
{beta}2 Glycoprotein I ({beta}2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome.
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beta2GPI forms stable complexes with PF4.
"In summary, this study makes evident that beta2GPI forms stable complexes with PF4, leading to the stabilization of beta2GPI dimeric structure that facilitates the antibody recognition."
Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids.
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beta2GPI domain V binds LDL-receptor-family LA modules.
"We found that the LA modules capable of binding beta2GPI-DV interact with the same region on beta2GPI-DV using residues at their calcium-coordination site."
Proteomics characterization of extracellular space components in the human aorta.
The binding of beta 2-glycoprotein-I to human serum lipoproteins: distribution among density fractions.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
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About 900 proteins detected in urinary exosome preparations.
"In pooled EPS-urine exosome samples, ~900 proteins were detected."
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I.
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MBL binds beta2GPI domains II and IV and activates complement.
"In this study, we provide evidence that mannose-binding lectin (MBL) binds to β2-GPI in Ca++ and a dose-dependent manner and that this interaction activates complement and promotes complement-dependent thrombin generation."
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway.
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beta2GPI inhibits contact activation of the intrinsic coagulation pathway.
"In the present study we report that beta 2-glycoprotein I inhibits the activation of the contact phase system of the intrinsic pathway of blood coagulation."
Studies on the possible function of beta 2-glycoprotein-I: influence in the triglyceride metabolism in the rat.
Activation of human post heparin lipoprotein lipase by apolipoprotein H (beta 2-glycoprotein I).
Novel interaction of apolipoprotein(a) with beta-2 glycoprotein I mediated by the kringle IV domain.
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beta2GPI binds apo(a) kringle IV.
"Coimmunoprecipitation experiments confirmed that beta-2 glycoprotein I and apo(a)/Lp(a) interact in human plasma and in cell culture supernatants of COS-1 cells, which ectopically expressed apo(a)."
Exocytosis of platelet dense granule content
Identification of APOH polymorphisms as common genetic risk factors for venous thrombosis in the Chinese population.
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A thrombosis-associated beta2GPI variant has less anticoagulant capacity.
"Functional tests indicated that the mutant β2 -glycoprotein I had a significantly lower capacity to extend thrombin clotting time and increase thrombin generation potential."
UniProt entry P02749 (APOH_HUMAN)
Affinage mechanistic annotation for APOH (human)