Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
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Human FPPS catalyzes the successive condensation of IPP with DMAPP and with GPP; it is the key branch-point enzyme of the mevalonate pathway and the target of nitrogen-containing bisphosphonate drugs. High-resolution structures of the human enzyme with risedronate/zoledronate and Mg(2+)/IPP define the catalytic mechanism.
"FPPS, a key branchpoint of the mevalonate pathway, catalyzes the successive condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate and geranyl pyrophosphate."
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
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Systematic UV-crosslink "interactome capture" in HeLa cells identified 860 candidate mRNA-binding proteins, including many metabolic enzymes; FDPS was among the captured proteins (basis for the HDA RNA-binding annotation).
"We identify 860 proteins that qualify as RBPs by biochemical and statistical criteria"
Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.
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Cloning, bacterial expression and characterization of human farnesyl pyrophosphate synthetase, studied in the context of cholesterol/sterol biosynthesis regulation in Hep G2 cells (basis for the TAS cholesterol-biosynthesis annotation).
"Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate"
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Expression of Farnesyl Diphosphate Synthase (FDPS)
FDPS dimer transfers IPPP to GPP
FDPS dimer transfers IPPP to DMAPP
holo-FDPS dimer binds NBPs
UniProt entry P14324 (FPPS_HUMAN), farnesyl pyrophosphate synthase
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Key isoprenoid-pathway enzyme that catalyzes formation of farnesyl diphosphate via sequential condensations; cytoplasmic; homodimer; Mg(2+)-dependent (2 ions per subunit); two catalytic activities EC 2.5.1.1 and EC 2.5.1.10.
"Key enzyme in isoprenoid biosynthesis which catalyzes the"