PMID:34445249

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability.

General review of the 69 SCF E3 ubiquitin ligase complexes, in which variable F-box proteins determine substrate specificity and target substrates for proteasomal degradation; does not specifically characterize FBXO47.

file:human/FBXO47/FBXO47-uniprot.txt

UniProt entry Q5MNV8 (FBX47_HUMAN), F-box only protein 47

UniProt FUNCTION and SUBUNIT for FBXO47 are inferred by similarity (ECO:0000250); FBXO47 is testis-enriched and contains an F-box domain (residues 41-91).

file:human/FBXO47/FBXO47-deep-research-falcon.md

Falcon deep research report for human FBXO47

FBXO47 is a meiosis-associated F-box protein that interacts with the SCF core component SKP1 and regulates meiotic chromosomal proteins (TRF2, HORMAD1) during meiotic prophase I.

"Most supported primary function: FBXO47 is a meiosis-associated F‑box protein that interacts with SCF machinery (via SKP1) and regulates key meiotic chromosomal proteins to ensure proper meiotic prophase progression."
In the meiotic context FBXO47 stabilizes the shelterin protein TRF2 (impairing its ubiquitination) at the telomere-inner nuclear membrane interface, rather than promoting TRF2 degradation.

"Ubiquitination assays indicate FBXO47 overexpression can **impair TRF2 ubiquitination** (without similarly affecting TRF1), consistent with **TRF2 stabilization**"
FBXO47 interacts with SKP1 and HORMAD1 and can target HORMAD1 for polyubiquitination/degradation, linking SCF activity to control of meiotic DSB homeostasis.

"FBXO47 interacts with SKP1 and HORMAD1 and targets HORMAD1 for polyubiquitination and degradation in HEK293T cells"
A 2024 model proposes FBXO47 acts in a centromeric SCF module that suppresses SKP1 ubiquitination to preserve centromeric SKP1 and promote centromere pairing and pachytene progression.

"FBXO47 is a component of a **centromeric SCF E3 ligase** and that FBXO47 can **reduce SKP1 ubiquitination**, helping preserve SKP1 levels at centromeres/chromosome axes"