Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae.
Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol.
-
Loss of inositol-pyrophosphate binding to the Pho91 SPX domain (K237A) activates Pho91-dependent export of phosphate from the vacuole to the cytosol in S. cerevisiae.
"The pho91K237A allele generates an amino acid substitution in the InsPP-binding patch of the Pho91 SPX domain."
NCU01540 re-review sequence comparison with Pho87/Pho90/Pho91 and Plt1
-
NCU01540 shares higher global identity with SF92 members (Pho91 48.6%, Plt1 50.2%) than with SF110 Pho87/Pho90 (about 40%), consistent with its PANTHER SF92 placement; the Pho91 K237 inositol-pyrophosphate-binding lysine aligns to NCU01540 K241.
"aligns to NCU01540 K241 (window RTGFSKVLKKF)"