Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria.
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Purified, reconstituted SLC25A42 is a mitochondrial transporter for CoA and adenosine 3',5'-diphosphate (PAP) that operates only by strict counter-exchange, importing CoA in exchange for intramitochondrial (deoxy)adenine nucleotides.
"The main physiological role of SLC25A42 is to import CoA into mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate."
Proteomic characterization of the human sperm nucleus.
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Large-scale sperm-nucleus proteome catalogue (403 proteins) in which SLC25A42 was detected; a high-throughput co-purification, not evidence of a nuclear function.
"403 different proteins have been identified from the isolated sperm nuclei"
A reference map of the human binary protein interactome.
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High-throughput binary (yeast two-hybrid) interactome reporting SLC25A42 interactions with keratins (KRT31, KRT34, KRTAP10-8) and MTUS2; underlies the bare protein-binding annotation.
"A reference map of the human binary protein interactome"
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
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SLC25A42 is detected in the high-confidence human mitochondrial proteome, consistent with its mitochondrial localization.
"Quantitative high-confidence human mitochondrial proteome and its dynamics"
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism.
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SLC25A42 and its paralog SLC25A16 are required in human cells for mitochondrial import of free CoASH, establishing the matrix CoA pool that supports CoA-dependent catabolism (TCA cycle, fatty-acid oxidation).
"SLC25A16 and SLC25A42 are critical for mitochondrial import of free CoASH"
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The disease variant N291D is a loss-of-function mutant that cannot import CoA and cannot rescue the mitochondrial CoA pool.
"the human disease mutant A42N291D is a loss-of-function mutant that cannot import CoA"
Vitamin B5 (pantothenate) metabolism
SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP
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Reactome reaction: SLC25A42 in the inner mitochondrial membrane exchanges cytosolic CoA-SH for mitochondrial matrix ADP (with in-vitro affinity also for dephospho-CoA and PAP).
"SLC25A42 associated with the inner mitochondrial membrane mediates the exchange of cytosolic CoA-SH for mitochondrial ADP"