Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
The heterologous siderophores ferrioxamine B and ferrichrome activate signaling pathways in Pseudomonas aeruginosa.
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FiuA and FoxA are produced only with ferrichrome or ferrioxamine B and their induction depends on adjacent ECF sigma/anti-sigma loci.
"The involvement of this putative regulatory locus in the specific induction of the ferrioxamine B and ferrichrome receptors has been demonstrated"
The ferrichrome uptake pathway in Pseudomonas aeruginosa involves an iron release mechanism with acylation of the siderophore and recycling of the modified desferrichrome.
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FiuA carries about 80% of ferrichrome uptake across the outer membrane, energised by TonB1.
"ferrichrome is transported across the outer membrane primarily (80%) by the FiuA receptor and to a lesser extent (20%) by a secondary transporter"
The role of FoxA, FiuA, and FpvB in iron acquisition via hydroxamate-type siderophores in Pseudomonas aeruginosa.
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FiuA is the outer-membrane transporter of ferrichrome-type siderophores; FpvB is a broad secondary route.
"FiuA is the TBDT of the ferric forms of ferrichrome, ferricrocin, ferrichrysin and RHODO"
Transcription regulation of iron carrier transport genes by ECF sigma factors through signaling from the cell surface into the cytoplasm.
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Ferrichrome uptake in Pseudomonas is mediated by the Fiu system, which includes FiuA.
"ferrioxamine B and ferrichrome uptake are mediated by the Fox and Fiu systems, which include the OM proteins FoxA and FiuA, respectively"
UniProt entry Q9I648 (Q9I648_PSEAE)